Aging is a natural process, but science is uncovering ways to better understand—and potentially slow—its progression. First published in the journal Cell, the “hallmarks of aging” framework outlines 12 biological processes that contribute to age-related decline. These hallmarks help researchers and wellness professionals identify how aging affects the body and how lifestyle, nutrition, and medical interventions may support healthier aging.

The 12 hallmarks include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and microbiome disturbance. Each of these mechanisms plays a role in how our cells age, lose function, and become more vulnerable to disease. For example, shortened telomeres can lead to cellular aging, while mitochondrial dysfunction affects energy production and vitality.

At Humansa, we believe aging is not just a biological process—it’s a personal journey. By understanding these hallmarks, individuals can take proactive steps to support their health and well-being. Nutrient-rich diets, regular exercise, stress management, and targeted supplements may help counteract some of these aging mechanisms. Our wellness programs, nutrition packs, and medical aesthetic services are designed to align with the latest scientific insights, helping clients feel empowered and energized at every stage of life. how

Whether you're exploring anti-aging solutions or simply seeking to age gracefully, Humansa offers expert guidance rooted in science and compassion. Discover small changes today can lead to a healthier, more vibrant tomorrow.

References

López-Otín et al. (2023). The Hallmarks of Aging: An Expanded Framework. Cell, 186(2), 243–279. Cell Journal